columbine essays

columbine expositions The disaster at Columbine High School is something that will be recalled and discussed for a long time to come. Individuals from the country over have all found out about this occasion. However, there are as yet two or three inquiries that individuals have. For example whos to fault? The children alone, the guardians for how they brought the kids up, or even really the understudies at Columbine? Most state that the guardians are to be faulted, however who really knows? As I would like to think the main two individuals that can really respond to this inquiry honestly are both dead. Everybody needs answers. Did the children have help? Who right? Who sold them the weapons and why? For what reason did they do this? How might they do this? I had a class about the last inquiry. Who could really go into a room and carry out a wrongdoing of slaughter in a school of individuals that you know and have grown up with? The vast majority of our group believed that they couldnt ever get enough rese ntment to do anything even remotely as terrible, however when you really consider it, in the event that you had no companions and where ridiculed constantly. It resembled your folks, educators, and even the entirety of your own docks where against you. I figure anybody could snap and possibly accomplish something as radical as this (Why at Columbine High). Did the young men, Dylan Klebold, 17, and Eric Harris, 18, have any assistance doing this wrongdoing. Starting at yet nobody has genuine proof that demonstrates they excepted they found who sold them the weapons. Police found around thirty little bombs and one twenty-pound propane bomb in the school, enough explosives to blow the school into practically nothing. Therefore individuals accept that the young men either needed to have help or they had visited the school ordinarily to design this ambush. Nobody talking however and no confirmation has been found. Their not just searching for data from somebody that could highlight someb ody that had helped theyre likewise searching for somebody that had realized this would occur, with the goal that they may discover the answ... <! Columbine articles The catastrophe at Columbine High School is something that will be recalled and discussed for a long time to come. Individuals from the country over have all found out about this occasion. In any case, there are as yet two or three inquiries that individuals have. For example whos to fault? The children alone, the guardians for how they brought the kids up, or even really the understudies at Columbine? Most state that the guardians are at fault, however who really knows? As I would see it the main two individuals that can really respond to this inquiry honestly are both dead. Everybody needs answers. Did the children have help? Who right? Who sold them the weapons and why? For what reason did they do this? How might they do this? I had a class about the last inquiry. Who could really go into a room and perpetrate a wrongdoing of slaughter in a school of individuals that you know and have grown up with? A large portion of our group believed that they couldnt ever get enough resentment to do anything even remotely as terrible, however when you really consider it, on the off chance that you had no companions and where ridiculed constantly. It resembled your folks, educators, and even the entirety of your own wharfs where against you. I figure anybody could snap and perhaps accomplish something as radical as this (Why at Columbine High). Did the young men, Dylan Klebold, 17, and Eric Harris, 18, have any assistance doing this wrongdoing. Starting at yet nobody has genuine proof that demonstrates they excepted they found who sold them the weapons. Police found around thirty little bombs and one twenty-pound propane bomb in the school, enough explosives to blow the school into basically nothing. Consequently individuals accept that the young men either needed to have help or they had visited the school ordinarily to design this ambush. Nobody talking however and no evidence has been found. Their not just searching for data from somebody that could highlight somebody that had helped theyre additionally searching for somebody that had realized this would occur, so that the... <! columbine articles From an entertaining animation on the historical backdrop of the United States to a profoundly moving dedication of the Columbine High school shooting episode, Bowling for Columbine tells, through cleverness and ruthless realities, a story that Americans need to hear. Coordinated, created, and composed by Michael Moore, this narrative is a reasonable and persuading account regarding weapon brutality in the United States. The narrative is a more than two hour mission we take with Moore as he moves here and there, looking for the inquiry: Why are Americans so fierce with one another? Instead of appearing to have an answer as of now as a top priority, Moore seems receptive. Above all else, Moore pulls off this feeling of objectivity from the very beginning, by clarifying his association with the NRA. At the point when he was a child, he clarifies, he wanted to shoot, having gotten a NRA marksmanship grant. Truth be told, when Moore visits NRA president Charlton Heston, he makes reference to that, even now, he is a deep rooted part. This is a brilliant move, since the NRA appears to stand apart as a reprobate in the film. Since, I expect, Moore needs to convince instead of just mention to the individuals on his side what they need to hear, it is a savvy choice on his part to appear to be a companion who is later sold out by the NRA. He interfaces the NRA with the KKK. While investigating the potential effects on Eric Harris and Dylan Klebold, the two secondary school understudies liable for the Columbine shooting. Moore visits, Lockheed Martin, the greatest U.S. arms producer. Lockheed Martin is, incidentally, situated in or close Littleton, Colorado, where the shooting occurred. Moore relates the mass demolition brought about by such atomic rockets made by Lockheed Martin and the mass decimation caused for a littler scope at Columbine. To this, the agent discloses to Moore that there is no connection between them, since the rockets produced there are utilized in the nation's safeguard, not in intentional assault. Quickly following this ... <! Columbine papers The Columbine catastrophe has struck another casualty a week ago. On the off chance that all contemplations were that the catastrophe was behind us, nobody has thought about the impacts of the slaughter. An understudy that was harmed in the slaughter was gaining ground on recuperating, when reaction from the catastrophe struck. Her Mother ended it all in regard to what the disaster has done to her life and her families life also. This is the impact that the occasion has produced, more agony and all the more misery. On seeing this case, we can gather the information that the entirety of our activities make an impact. In the end the entirety of our belongings find us be it through outward powers or inside ourselves. Being people that are consistently in contact with others, we have a characteristic option to regard the way that what we do has a direction on everyone around us. The effect of the columbine disaster is as yet being felt and will keep on doing as such for quite a while. Each time an understudy hopes to see their companion in the foyer that was killed, the impact is felt. Consistently a kid that was harmed glances in the mirror and sees somebody other that themselves, the impact is felt. As the youngsters that caused this disaster watch their prospects become more swindled with torment and enduring, the impact is felt. A day that changed the course of people groups lives and will keep on for the remainder of their lives. We as people need to figure out how to regard to truth that we are so significant in the lives of others. The impacts are the equivalent in circumstances where terrible exceeds the great and where great exceeds the awful. The impact will keep on being felt when you show a kid something new, help somebody out of luck, or simply indicating somebody you give it a second thought. The positive attitude remain with these individuals and ideally the impact will be them helping other people for your benefit. Affecting an individual with the intensity of graciousness can thus cause them to do likewise. As much as brutality is predominant t ... <!

John Rawls Philosophy of Liberalism Strengths and Weaknesses

Presentation John Rawls have built up an exhaustive hypothesis that can be helpful in tending to contemporary issues. One of the significant points of interest of his hypothesis is that it contains significant rules that can be relevant nowadays.Advertising We will compose a custom exposition test on John Rawls’ Philosophy of Liberalism: Strengths and Weaknesses explicitly for you for just $16.05 $11/page Learn More Rawls’ theory can be utilized while tending to the contemporary issues related with inconsistent dispersion of assets. It is additionally important to take note of that Rawls’ reasoning of progressivism depends on standards of equity, yet there are as yet certain shortcomings in the hypothesis. Qualities of Rawls’ Philosophy As has been referenced over the way of thinking can have explicit ramifications in the contemporary society. The significant quality of the way of thinking is that it furnishes individuals with a particular device to mainta in a strategic distance from any inclination. The â€Å"veil of ignorance† is a powerful method to build up specific standards to administer a general public (Shaw Barry, 2012). Along these lines, individuals will never make a tyrant society as the chances to be in the horrible position are excessively high. On account of the shroud of numbness, individuals will attempt to make the general public where the less wealthy individuals will have every conceivable right. Aside from rights, these gatherings of individuals will have various chances, which will make sure about acknowledgment of capability of the most dynamic and talented people.Advertising Looking for paper on reasoning? How about we check whether we can support you! Get your first paper with 15% OFF Learn More Admittedly, the current way of thinking can turn into a decent answer for the current issues related with inconsistent dispersion of assets. Presently less wealthy individuals have not many open doors contraste d with all the more wealthy gatherings. Outstandingly, this is one of the significant issues related with inconsistent conveyance of assets which prompts steady debasement as just confined number of advancement happens. Rawls’ reasoning tends to the issue of the absence of chances. Another quality of the way of thinking is that it doesn't disregard disparity which is a trademark highlight of the human culture. Despite what might be expected, Rawls legitimizes it and even demonstrates that disparity is one of the variables adding to improvement of the human culture. Rawls builds up a model of society where minimal wealthy gatherings will have more assets, rights and openings than those in a nonexistent society where all are equivalent. Along these lines, there is no need in attempting to reduce disparity, which is essentially unthinkable. As indicated by Rawls’ reasoning, individuals can concentrate on making a general public where imbalance is an apparatus of advanceme nt. The Major Weakness of Rawls’ Philosophy As has been referenced above, there is sure shortcoming in the way of thinking. Along these lines, there are very hardly any apparatuses to keep up the new request. As per Rawls’s reasoning, correspondence is unimaginable as individuals are ‘victims’ of a â€Å"genetic lottery† (Shaw Barry, 2012, p. 126). A few people will unavoidably gather more assets and there is no assurance that these individuals will stay following the standards worked out. All the more wealthy individuals can deny less wealthy individuals of their privileges and, all the more significantly, opportunities.Advertising We will compose a custom paper test on John Rawls’ Philosophy of Liberalism: Strengths and Weaknesses explicitly for you for just $16.05 $11/page Learn More Conclusion It is conceivable to take note of that Rawls’ reasoning can be appropriate in the contemporary world as it tends to significant issues relat ed with inconsistent dispersion of assets. Support of imbalance can be viewed as one of the significant qualities of the way of thinking. Simultaneously, the nonattendance of devices to keep up the made society is one of its significant shortcomings. Obviously, the way of thinking has qualities and shortcomings, yet note that it is an important wellspring of information that can be utilized to address significant issues related with inconsistent appropriation of assets in the contemporary world, which prompts certain corruption of the human culture. Reference List Shaw, W.H. Barry, V. (2012). Moral issues in business. Belmont, CA: Wadsworth Publishing. This exposition on John Rawls’ Philosophy of Liberalism: Strengths and Weaknesses was composed and presented by client Helen Lamb to help you with your own examinations. You are allowed to utilize it for research and reference purposes so as to compose your own paper; in any case, you should refer to it as needs be. You can give your paper here.

Tips for the Brokenhearted After a Relationship Ends

Tips for the Brokenhearted After a Relationship Ends Depression Treatment Print Tips for the Brokenhearted After a Relationship Ends Practical Advice for Coping and Healing By Nancy Schimelpfening Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be. Learn about our editorial policy Nancy Schimelpfening Reviewed by Reviewed by Amy Morin, LCSW on January 24, 2020 facebook twitter instagram Amy Morin, LCSW, is a psychotherapist, author of the bestselling book 13 Things Mentally Strong People Dont Do, and a highly sought-after speaker. Learn about our Wellness Board Amy Morin, LCSW Updated on February 17, 2020 JGI / Jamie Grill / Getty Images More in Depression Treatment Medication Causes Symptoms Diagnosis Types Childhood Depression Suicide The pain of an ended relationship is one that many people experience, maybe even more than once in a lifetime. Movies and books make it seem easy to bounce back after a broken heart: The happy endings either see a couple getting back together or someone moving on to an even better relationship.   In real life, relationship woes aren’t usually resolved in two hours like they are on the silver screen, and the stories don’t always have tidy endings.   If you’re trying to come to terms with the end of a relationship, commonly repeated platitudes, adages, and cliches are not likely to be helpful.?? Although people may mean well when they say, “It’s better to have loved and lost than never to have loved at all,” offering such sentiments doesn’t give you much by way of practical advice for coping with your emotions.   Healing from heartbreak is not the same process for everyone. It may even vary within the same person throughout their life, changing from one relationship to the next.   Nobody can tell you with any degree of certainty how long you will need to heal, but there are some ways you can make the process of mending a broken heart into an opportunity to learn more about your wants and needs.   Ultimately, you can use these insights to develop and strengthen your healthy coping skills. The growth you experience will help you navigate future relationships with others, as well as the relationship you have with yourself.   Knowing When to End a Relationship Ways to Mend a Broken Heart In the immediate aftermath of a breakup, know that it’s OK to allow yourself time to grieve the loss. You don’t need to jump straight into problem-solving modeâ€"in fact, doing so when you haven’t allowed yourself to fully embody your feelings may make the process more protracted and difficult.   In the early days, try to resist the urge to isolate yourself. Sadness, guilt, confusion, and other intense feelings may be overwhelming. Reach out to the people who care about you. To come to terms with the changes in your life, you’ll need the support of your family and friends.   When you’re ready for the next step, here are some dos and don’ts to help guide you through the process of healing.   Dont Let Your Emotions Rule   Try not to view the end of a relationship as a failure. Instead, think of it as an opportunity to learn and grow.??  It doesn’t matter if it was your first relationship or if you’ve had others before. Everyone, whether they’re 15 or 50, can get to know themselves better and work on improving their relationship skills.   You may have a lot of anger around the relationship, including the way it ended. You may even be tempted to “exact revenge” on your ex or fantasize about interfering in or disrupting their lifeâ€"including new relationships.   Remember that hurting another person won’t lessen your pain. In fact, it’s more likely to make you feel worse and will slow the progress of your own healing.   Do Take Care of Yourself   Good self-care is emotional, physical, and spiritual. You have your own unique needs in each area, but there are some general acts of self-care that are beneficial for almost everyone such as a nutritious diet, regular exercise, a social support system, and strategies for coping with stress, to name a few. Try to be patient, gentle, kind, and giving toward yourself. It may help to know that the pain of a break-up is not just emotional; research has shown people can also feel physical pangs of loss.?? Physical Consequences of Emotional Pain You may also need to work on restoring the “big picture” perspective. When you’re in a romantic relationship it may be a central part of your life, but romantic love isn’t the only kind that can be nourishing. Continue to nurture relationships with friends, family, and yourself. If you feel guilt or shame about your role in a relationship that has ended, it may be hard to be a good friend to yourself as you work through these feelings. Keep in mind that practicing compassion toward yourself makes it more likely you’ll attract that kind of energy from others.   If you find you cannot let go of a relationship or feel you are unable to cope with the loss (even with support from friends and family) as time goes on, you may want to seek counseling.   Working with a trustworthy, knowledgeable, skilled, and compassionate therapist is good self-care during any period of major change in your life, but can be especially helpful when you’re coping with loss. How to Find the Right Therapist Don’t Get Stuck in the Past We all have the tendency to look back on our lives, or certain relationships, with “rose-colored glasses.” The effect of “rosy retrospection” is that you may refuse to see the problems and only focus on the good parts (which you’re likely to miss).??   Sometimes, both the good and bad memories may feel as though they’re playing on an endless loop in your mind. These intrusive thoughts can slow down the process of healing and can be quite distressing.??   Though it may be difficult, try not to lose perspective. No relationship is all bad, but none are perfect either. If you are glorifying the relationship or find you continue to put your ex on a pedestal, it may be a sign that you need to give yourself some emotional and perhaps physical distance.?? For example, you may struggle in the digital age to refrain from “checking up” on your ex via social media.?? If you can’t resist the temptation, it may be time to unfriend them or block their profile.   You won’t be able to move on with your own healing if you’re constantly being drawn back into their lives and thinking about what once was, as well as what will never be.??   If your ex starts a new relationship, seeing them post on social media (even if it’s not always an accurate representation of reality) may cause old feelings to resurface for you. It can also fuel preoccupation with any unresolved aspects of your relationship with them.   Do Appreciate the Good Memories Even if your relationship ended on a sour note, chances are it was not all bad. It’s normal to look back at what was good about it and you may find you miss certain things about your ex and the love you shared.?? At the same time, you may feel overwhelmed by the empty space that’s left when the relationship ends or harbor resentment about what happened that lead to its dissolution.   Riding out these shifts in emotions is part of the healing process. When a happy memory comes up, allow yourself to be grateful for itâ€"then move on. Why Break-Ups Happen Don’t Deny Your Needs Being honest with yourself about your needs (especially those that aren’t being met) can be a painful process. You may feel it would be easier, and less painful, to simply ignore them.  ?? While it may feel better in the short term to “numb” yourself to the hurt, it will only make it harder for you to heal in the long term.  Pretending you don’t have needs makes it impossible for you to grow, both in your relationships with others and the one you have with yourself.   Do Reevaluate Your Needs Following a break-up is a good time to think about your wants and needs in a romantic relationship. You may find it helpful to journal or make lists.   Ask yourself questions like, “Have I been choosing partners who are not capable of a loving and mature relationship?” and “Was I hoping this person would change, or that I would be able to change them?”   It can be painful to admit that your previous relationship wasn’t able to meet your needs. Taking the time to honestly reflect can be hard work, but once you do, you’ll be able to clarify the qualities to look for in a future partner.   Don’t Jump Into a Rebound Relationship You may feel a sense of urgency about finding a new romantic partner, but so-called “rebound” relationships prevent you from working through your previous one.?? If you don’t take time to reflect on a relationship that has recently ended, you may end up repeating patterns or making the same mistakes in a new one. It can be hard to break free from old ways of thinking and behaving, even if you know it’s not helpful. But recognition is the first step to making changes.   Do Try Again When You’re Ready Sometimes, people have a hard time coping with being single when they had become used to being part of a couple.?? This may be especially true after a long-term relationship ends.   If you’re struggling with your identity as a single person,?? try to remember that your value comes from who you are, not who youre with.   Being on your own gives you the opportunity to focus on yourselfâ€"though this can be hard if you are used to taking care of others and generally find it easier than thinking about your own needs.   Sometimes, people who arent as confident socializing on their own are more comfortable in social situations when theyre part of a couple. Others may enjoy being social whether they’re in a relationship or not, but they might resist going out after a break-up. The tendency to avoid social situations is often a mix of worrying about seeing an ex-partner or someone you know who might ask about the relationship combined with wanting to avoid places, activities, and people who would remind you of an ex. Try not to isolate yourself. You certainly don’t have to go out on Friday night if you’d rather stay at home with a book, but if you do feel like spending time around others and just dont want to go out on your own, ask a friend to tag along.   What Is Mindful Dating? While you don’t have to rush it, you may begin to open up to the possibility of another relationship as time goes on. It might be scary to think about falling in love againâ€"especially after you’ve been hurtâ€"but try to remember that as deep as the pain of a broken heart can be, it means that you experienced love just as deeply. You may not even be looking for a relationship when love finds you, as it can show up in unexpected places. If you are looking more intentionally, be open to meeting others when you go out and choose the places and activities you enjoy. Whether a church group, sports team, or the local library, you’re more likely to make positive connections with others and find lasting relationships (friends and romantic partners alike) in places where you feel safe and comfortable being yourself.   5 Psychological Theories of Love Do Forgive   Forgiving your ex may take time and may not come easily, especially if you were hurt or betrayed. Its important to note that forgiving someone does not mean that you condone their hurtful behavior and actions. In fact, sometimes, the act of forgiveness is not so much about the other person. Arriving at a place of forgiveness gives you permission to stop investing time and energy into a person and situation that is no longer healthy for you. To mend a broken heart and move on, theres someone else you need to be ready to forgive: yourself. You may find it easier to forgive your ex, but remember that the longest-running and the most powerful relationship you’ll ever have is with yourself. You cant change the past, but you can learn from it. Whether you’re single or in a relationship, you can always change behaviors or shift your paradigm to prevent repeating mistakes, allow yourself to grow, and continue to develop self-love. How to Forgive Yourself

Why Using Experiential Learning With Adults Is Powerful

Kolb and Frye, two leaders in adult educational theory, say that adults learn best through active participation and reflection. This form of learning is called experiential because it involves hands-on experience and observation as well as discussion and other forms of learning. What Is Experiential Learning? In a sense, experiential learning is simply learning by doing -- but there is more to the process. Not only do learners take action, but they reflect on, learn from, and take new action based on experience. Kolb and Frye describe experiential learning as a four-part cycle: The learner has concrete experience with the content being taught.The learner reflects on the experience by comparing it to prior experiences.Based on experience and reflection, the learner develops new ideas about the content being taught.The learner acts on her new ideas by experimenting in an experiential setting. When the new ideas are put into action, they become the basis for a new cycle of experiential learning. Examples of Experiential Learning Its important to understand that experiential learning is not identical with hands-on learning or apprenticeship. The purpose of experiential learning is not simply to learn a skill through practice, but also to think critically about the practice and to improve upon it. For a child, hands-on learning might involve mixing baking powder and vinegar and watching it bubble and rise. This activity is good hands-on fun, but it doesnt necessarily provide the child with a full understanding of the chemical interaction between the two materials.   For an adult, hands-on learning might involve working with a trained carpenter to learn how to build a chair. In this case, the learner has gained some skills -- but has not taken part in experiential learning. The next step would involve taking time to reflect on the experience and compare chair-building to other building projects. Based on reflection, the learner would then develop new ideas about how best to go about building a chair and return to chair building with new insights and ideas. Pros and Cons of Experiential Learning Experiential learning can be very powerful for adults because they have the life experience and cognitive ability to reflect, develop new ideas, and take positive action. It also provides adults with the real-world experience they need to place their new skills in context and to develop new ideas about how to implement their skills. This is particularly true when real-world skills are taught in a classroom context. For example, a classroom experience with providing CPR is very different from a real-world experience in the back of an ambulance. On the other hand, experiential learning has very specific limits. It is only useful when the  content being taught is content that will be used in a real-world setting. So, for example, it is very difficult to provide experiential learning relative to literature, history, or philosophy. Yes, it is possible to take field trips to relevant locations or museums -- but field trips are quite different from experiential learning.

Demo Speech on Wrapping a Gift - 754 Words

Sarah Del Rio Speech 100 Demonstrative Speech General Purpose: To demonstrate Specific Purpose: To demonstrate to my audience how to wrap a present. Central Idea: To demonstrate to my audience how to make wrap a present by first discussing how to choose the appropriate gift wrapping paper for your event, second, by talking about the supplies that will be needed, third, I will explain step by step how to wrap the present, finally, I will tell you about the finishing touches you can add to your gift. INTRODUCTION: I. Hello my name is Sarah Del Rio and today I will be demonstrating for you how to wrap a present. I have selected this topic to show you today because it is something simple thing that everyone will need use at†¦show more content†¦The first step is to get the appropriate wrapping paper. B. The second step is to gather all the supplies. C. The third is to follow the instruction in wrapping the present. D. The fourth step is to add the finishing touches. II. If you didn’t have this skill down before now you do and I hope it comes in handy, which I’m sure it will for all ofShow MoreRelatedPersuasive Speech1641 Words   |  7 PagesPublic Speaking 14 November 2010 Persuasive Speech Reduce Landfill Waste by Reduce, Reuse and Recycling and the financial benefits I. Introduction A. Attention Getter: Over half of the waste that ends up in the landfill does not belong there because it could have been recycled or reused. B. Credibility Statement: Not only do I religiously practice reducing, reusing, and recycling, but I have done a great deal of research for this speech, also research for a recycling project in myRead MoreProject Mgmt296381 Words   |  1186 Pagesexperience and/or information to determine the project duration and total cost. These estimates are sometimes made by top managers who have very little knowledge of the processes used to complete the project. For example, a mayor of a major city making a speech noted that a new law building would be constructed at a cost of $23 million and would be ready for occupancy in two and one-half years. Although the mayor probably asked for an estimate from someone, the estimate could have come from a luncheon meetingRead MoreStephen P. Robbins Timothy A. Judge (2011) Organizational Behaviour 15th Edition New Jersey: Prentice Hall393164 Words   |  1573 Pagesmake the same decision?† 2. Recognize that failure is not always bad. Most of us would agree that we have learned more in life from our mistakes than from our successes. So, we need to realize that while we don’t want to fail, it does have a hidden gift if we’re willing to receive—a chance to learn something important. Eli Lilly holds â€Å"failure parties† to honor drug trials and experiments that fail to achieve the desired results. The rationale for these parties is to recognize that when little is

Htc Company Analysis Free Essays

Running head: HTC CORPORATION 1 HTC CORPORATION INSHA SHAH UNIVERSITY OF AKRON Running head: HTC CORPORATION 2 HTC AT A GLANCE HTC Corporation (originally High Tech Computer Corporation) is a smart phone manufacturer founded in 1997 and based in Taiwan, as an outsourcing company. HTC Corporation prides itself on offering open source mobile phones which are easy for both developers and users, and has quickly established its reputation as a leading company behind many of the markets most popular operated branded-devices. According to the HTC profile on the Wikipedia Online Encyclopedia HTC retains approximately 13,000 employees. We will write a custom essay sample on Htc Company Analysis or any similar topic only for you Order Now They follow the typical tall organizational structure with many layers between workers and the CEO. It is highly centralized: top decisions are made by the CEO of the company. HTC Corporation has launched several major HTC- Branded products on the international market with the intention of becoming the leading innovative supplier of mobile information and communication devices. In fact, HTC Corporation was the first on the international market to offer the Android mobile device platform through its HTC Dream hardware, marketed as the T-Mobile G1 model. In support of this, HTC Corporation has expanded its technological and marketplace strength through partnership with major player Microsoft and leading mobile phone operators of Orange, O2, T-Mobile, Vodafone, Cingular, Verizon, Sprint and NTT DoCoMo (â€Å"HTC. Com†). Most recently in Australia, HTC Corporation launched its three latest handsets- HTC Snap, HTC Touch Diamond2 and HTC Touch Pro2 to add to its 11 devices currently in the Australian market. The new technology founded in these highly popular products is designed to be finger-touch friendly, with improved mobile integration technology, and dual microphone and speakers. The HTC Corporation’s newest feature is the â€Å"inner circle† which allows the users to bring emails from a preselected group to a top of their inbox, making business on the go even easier (â€Å"mobile. com†). HTC Corporation Product Innovation includes: ? ? ? ? ? ? Open Handset Alliance Smartphone S Series ( Smartphone) T Series (Touch Phone) P series (PDA Phone) X Series ( Mobile Computer) A Series ( Android Phone) According to the source of mobile. com, HTC now specializes in providing its own and other operator branded products in addition to its original equipment manufacturer partners. HTC has a subsidiary company, Dopod, a Taiwan-based manufacturer of Windows Mobile Smartphones. As a company, HTC Corporation has gone from strength to strength, with HTC receiving recognition as the second-best performing technology company in Asia in 2007 by BusinessWeek, and the number three spot in its Global Listing in 2006. Running head: HTC CORPORATION 3 The size of the corporation can be classified in two ways: (I) by revenue and (II) by market capitalization. According to the report from Taiwan Economic News, HTC’s Market Capitalization has recently climbed to $438 billion. Also the corporation shipment and revenue continues to grow to $9. 449 billion. COMPANY PERSPECTIVE Their mission is to become the leading supplier of the mobile information and communication devices by providing value added designs, world-class manufacturing and logistics and service capabilities. HTC continues to establish a high volume manufacturing facility and its focus on high wireless capability. They intend to develop a software team capable of creating a world class consumer and business application that will enhance the value of their hardware. HTC is dedicated to the belief that each mobile device needs to fit its owner. Their goal is to make a product of observing, honoring how individuals choose to interact with a technology. Their mission is to strengthen the relationship through innovative design strategies and sophisticated branding initiatives (â€Å"HTC. com†) HTC’s vision is to address the communications and administration needs of a professional organization of all sizes with intuitive platforms and sophisticated branding initiatives. Their focus is to make people’s ives easier through mobility and convenience. They want users to be able to talk to friends and relatives, read books and access the internet on one device. With their smartphone they have started to see this vision come true (â€Å"HTC. Com†). HTC’s values: ? ? ? Excellence in everything they do Commitment to clients, brands, projects and industry. Honor in dealing with clients, suppliers, employees (â€Å"fastcompa ny. com†) CULTURE AT HTC HTC prides itself on its cutting-edge technology and innovative spirit. From studying its own website, HTC’s culture is competitive and diverse. Under the â€Å"Careers† tab, nine different employees’ pictures are featured with a video advertising HTC’s appeal as an employer. Five of the nine employees pictured are women; three are women of color, and all nine employees appear to be under the age of 40. HTC’s culture is hip, diverse, and fastpaced. The video stressed that technology is constantly improving and the â€Å"best idea† rather than the â€Å"biggest title† moves forward. This shows that the culture at HTC values creativity and competition (â€Å"HTC. Com†). HTC makes annual donations to the Social Welfare and Charity Foundation or Educational Foundation. This foundation funds leadership and character training for elementary, junior high and senior high students, cosponsors local community development and urban cultural revitalization efforts, targets the special needs of disadvantaged groups, and provides disadvantaged children opportunities to further their academic careers. Running head: HTC CORPORATION 4 The HTC Foundation established the nation’s first institute dedicated to character-building and English training in the Hualien’s Meilun District. The institute provides character-building and English enhancement curricula free of charge to fourth grade elementary school students from around Hualien County. In addition, the Foundation offers scholarships for children with special financial needs and financial aid to low-income families and sponsors after-school tutoring programs. Each year, Foundation disbursements benefit over 2,000 youth from disadvantaged families both in Taiwan and overseas (â€Å"HTC. Com†). HTC STRATEGY HTC Corporation uses a differentiation strategy to attract customers looking for more choices. HTC expects differentiation product in terms of innovation and execution. They focus on innovation and execution to enhance product proposition and offer consumers a variety of products. When they think of increasing the quality and the variety of the product, they first consider what the customer will value. They are offering a wide range of product lines to outperform their competitors like Apple and Nokia. HTC has produced an amazing number of phones, all of which have an impressive array of applications and features. They do have the cutting edge when it comes to hardware, but if a consumer can’t afford these more expensive versions HTC’s older models (like the Hero) are still well built and functional. In addition, HTC offers a variety of body forms and builds, including some devices with physical keyboards (â€Å"htc. com†). FINANCIAL POSITION To shadow on the financial stability of the HTC CORP I used liquidity ratio and leverage ratio. The liquidity ratios measure the company’s ability to cover its expenses. The two main liquidity ratios I used to analyze the company’s financial health are current ratio and quick ratio (â€Å"investing. businessweek. om†). 1) The Current Ratio is a reflection of financial health. It is the number of times company’s current assets exceeds the current liabilities, which is the indication of the solvency of that business. The formula to compute the current ratio is Using the earlier Balance Sheet data of the HTC C ORP, we can compute the company’s current ratio as: = = 1. 3 times This tells us that the current liabilities are covered by current assets by 1. 3 times. The HTC CORP is able to cover their short term expenses which are meant to be covered with in a period of one year. 2) The Quick Ratio is also called the acid test ratio. This is because it looks at the company’s most liquid assets and compares them to current liabilities. The quick ratio tests whether a business can meet its obligation even if adverse conditions occur. The formula to compute the quick ratio is: Assets considered being quick assets include cash, bonds, stock, and accounts receivable. Using the Balance Sheet data of the HTC CORP, we can compute the quick ratio of the company as: Running head: HTC CORPORATION = = = 1. 1 times 5 This indicates that the ratio is considered satisfactory, as long as the collection of the receivables is not expected to slow. So the HTC CORP seems to have adequate resources to cover its debts. In order to identify the long term coverage of the company, we are focusing on one of the main leverage ratios. Leverage ratio measures the stability of a company and its ability to repay its debts. These ratios are of particular interest to banks. They should be of interest to shareholders as well since it gives the strong indication of the financial health and the viability of the business. 3) The Debt-to Equity Ratio is a measure of how dependent a company is on a debt financing as compares to owners equity it shows us how much of a business is owned and how much is owed. The Debt-to-Equity ratio is computed as follows: Using the Balance Sheet data of the HTC CORP we can compute the debt-to equity ratio: Times Since the Debt-to-equity ratio is greater than 1, i. e. , (1. 8 times), the capital provided by the lenders exceeded the capital provided by the owners. But because of the greater ratio it has high risk defaults too. It varies with the type of business and the risk attitude of management. Year over year HTC has been able to grow over their bottom line from $29 billion to $59 billion primarily through revenue growth ($142. 9 billion to $277. 7 billion). For a while the costs associated with cost of goods sold, and income tax all increased as a percentage of sales, the growth in top lines revenues contributed enough to still see net income. HTC Corporation uses little or no debt in its capital structure and may have less financial risk than the industry aggregate. Accounts Receivable is typical for the industry, with 58. 31 days worth of sales outstanding. Lastly, HTC Corporation is among the least efficient in its industry at managing inventories, with 30. 39 days of its Cost of Goods Sold tied up in Inventories (â€Å"investing. businessweek. com†). Therefore the overall financial tability of the corporation is stable and healthy. They have adequate resources to cover their debts and unforeseen uncertainties. MY CAREER at HTC Yes, HTC could be good place to obtain my first career oriented-position. HTC is the part of the global market that breeds flexibility, new technologies and innovation. It will create a platform for the new opportunities to explore and do creative things. I fit the HTC profile of being young, educated and a global citizen: while growing up in Kashmir and going to college in America, I’ve relied on technology and most recently, my own smartphone, to navigate my day. I would bring creativity and a fresh perspective to HTC’s worktable. Running head: HTC CORPORATION REFERENCES Bloomberg Businessweek. (2012, April 10). Retrieved from http://investing. businessweek. com/research/stocks/financials/financials. asp? ticker=2498:TT 6 HTC Corporation. (n. d. ). Retrieved from http://www. htc. com/us/about/careers/industrial-designer-corporate-strategy-office/422 HTC Corporation. (n. d. ). Retrieved from http://www. htc. com/us/about/social-responsibility HTC. (n. d. ). In Wikipedia Online Encyclopedia. Retrieved from http://en. wikipedia. org/wiki/HTC How to cite Htc Company Analysis, Papers

Protein Ligand Interaction-Free-Samples for Students-Myassignment

Question: Discuss about the Protein Ligand Interaction. Answer: Introduction Oxidative phosphorylation is the process that involves the formation of ATP and constitutes the fundamental and most important means of energy production for the cells of animal, plant and bacterial origins (Jonckheere, Smeitink Rodenburg, 2012). Apart from oxidative phosphorylation, photophosphorylation is also involved in the synthesis of ATP and both these processes are dependent on the F1F0-ATPase enzyme complex for catalyzing the ATP synthesis (Nath Villadsen, 2015). The F1F0-ATPase enzyme is also called the ATP synthase enzyme. The source of energy that helps to carry out ATP synthesis is an electrochemical proton gradient. This proton gradient is produced by the electron transfer complexes that are present in the mitochondria, chloroplast or the bacterial membranes (Jonckheere, Smeitink Rodenburg, 2012). This essay describes the protein ligand interactions with respect to the F1F0-ATP synthase enzyme complex (protein) and ATP(ligand). Interaction between F1F0-ATPase and ATP In prokaryotes, the F1F0-ATPase enzyme complex consists of 8 different sub-units while in mammals the number of sub-units are 16-18. The molecular weight of the enzyme typically ranges between 550-650kDa. It is located in the bacterial plasma membrane, while in plants it is located in the thylakoid membrane of the chloroplasts and mitochondrial inner membranes and in animals it is located in the inner membranes of the mitochondria. The enzyme consists of 2 parts designated F1 and F0. The F1consists of 5 sub-units, designated 3, 3, , and . The F0 part on the other hand consists of 3 sub-units designated a, b and c. The stoichiometry of the a, b and c sub-units of the F0 is ab2c10-14(Hahn et al., 2016). The 2 parts of the enzyme complex, which includes F1 and F0 are connected to each other by 2 stalks, a central one and the other a peripheral one. The central stalk consists of the and sub-units, while the peripheral stalk comprises the and b sub-units. Interactions between F1 and F 0are said to be coupled and disruption of the interactions results in the loss of energy transduction and the system assumes an uncoupled state. Each of the 3 sub-units present in the F1consists of catalytic sites for ATP synthesis. The molecular interactions involved in the synthesis of ATP by the F1F0-ATPase was proposed by Paul Boyer and it was called the rotational catalysis mechanism or the binding change or alternating site hypothesis (Capaldi Aggeler, 2002). According to this mechanism or hypothesis, the 3 active sites of the F1 part of the enzyme complex participates in the catalysis of ATP synthesis. One of the sub-units binds ADP and Pi, thereby assuming the -ADP conformation. The sub-unit then assumes a -ATP conformation by tightly binding to ATP and bringing about an equilibration of both ATP and ADP/Pi on the surface of the enzyme. On assuming the -empty conformation, the sub-unit loses its affinity for ATP and as a result the newly synthesized ATP then is released from the enzyme complex. The next round of catalysis begins when the sub-unit again binds to ADP and Pi and assumes the -ADP conformation. During the catalysis reactions, the 3 sub-units interacts and assumes the conformations in such a way that one is in the -ATP conformations, while another is in the -ADP conformation and the third is in the -empty conformation. The conformational changes are brought about by the passage of protons through the F0 portion of the F1F0-ATPase. The streaming of the protons through the pore of F0, results in the rotation of the cylinder part of F0 composed of the c sub-units and the sub-units along its long axis. The rotation is about 120 degrees and results in the contact of the sub-unit with each and every catalytic sub-unit, thereby forcing them to assume the -empty conformations (Nelson, Cox Lehninger, 2012). Th ese conformations of the sub-units are also called the open, partly open and closed conformations, where the open conformation binds ATP or ADP/Pi. Binding of ATP and the closure of the open site, results in a conformational change of the remaining catalytic sub-units that results in the partly open sub-unit to attain the open conformation and the closed sub-unit to attain the partly open conformation (Capaldi Aggeler, 2002). Proton transport is dependent on the a and c sub-units of the F0 portion of the F1F0-ATPase. And the amino acid residues aspartate at position 61 of the c sub-units and Arginine at position 210 of the a sub-units are critical for carrying out the function of the proton transport. The rotation of the c sub-units takes place relative to that of the a sub-unit. The rotor stalk composed of the and sub-units are firmly attached to the c sub-units at the base, while interacting with the and sub-units at the top. The stator stalk consists of the b2 and sub-unit s, where the b2 interacts with the a sub-units and the interacts with the sub-units. Moreover, the arginine residue at position 376 of the sub-unit is involved in the generation of the transition state structure of the catalytic sub-units during steady state catalysis. The positive charge of Arg376 along with those of Lys155 and Arg182, results in the formation of a Pi binding pocket. Binding of Pi prevents the binding of ATP. Upon formation of the partly open -ADP conformation, the movement of the C- terminal region of the enzyme along with the nucleotide binding domain results in the re-positioning of the catalytic side chains, designated Glu181 and Arg182. Thus, this step involves priming of the catalytic site for subsequent catalytic steps. The next step involves transition from ADP/ Pi to ATP. This is brought about by the rotation of the sub-unit that results in the movement of the sub-unit towards the and the subsequent movement of the Arg376 and Arg182 towards ADP. Co-o rdination of a Mg2+ along with the residues Arg376, Lys155 and Arg182 brings about the synthesis of ATP. The sub-unit then undergoes further rotation resulting in the withdrawal of the Arg376 from the catalytic site, thereby causing the release of the ATP (Senior, Nadanaciva Weber, 2002; Martin et al., 2015). Figure 1: The arrangements of the sub-units of the ATP synthase enzyme complex. (Source: Capaldi Aggeler, 2002) Figure 2: Proton motive force and ATP synthesis mechanism. (Source: Senior, Nadanaciva Weber, 2002) Figure 3: The various conformations of the catalytic site of the enzyme. (Source: Source: Capaldi Aggeler, 2002) Oxidative phosphorylation and photophosphorylation The oxidative phosphorylation is the metabolic pathway that is involved in the oxidation of nutrients in order to release energy in the form of ATP. Oxidative phosphorylation involves the occurrence of redox reactions with the help of which electrons are transferred to electron acceptors like oxygen from the electron donors. The flow of electrons is called the energy transport chain. The energy released is used in the transport of protons. Here the ATP synthase enzyme utilizes the energy of the proton gradient to convert ADP to ATP. It is the last enzyme of the oxidative phosphorylation pathway (Bazil, Beard Vinnakota, 2016). Apart from oxidative phosphorylation, photophosphorylation is another process that utilizes the ATP synthase enzyme to carry out phosphorylation of ADP to ATP during photosynthesis. Th transfer of electrons helps to generate a proton motive force that helps in the activation of the ATP synthase enzyme (Junge Nelson, 2015). Inhibitors The DCCD is the classical inhibitor of the ATP synthase. It functions by modification of the proton binding site present in the c sub-unit. It causes steric hindrance of the movement of the c sub-unit relative to the a sub-unit, thereby preventing the rotation of the F0F1 complex (Toei Noji, 2013). Conclusion Thus, it can be concluded that the ATP synthase is an integral part of the metabolism and energy production pathways of various organisms and the intricate molecular interactions of ATP with the enzyme complex constitutes the highlight of such an important metabolic reaction. Reference List Bazil, J. N., Beard, D. A., Vinnakota, K. C. (2016). Catalytic coupling of oxidative phosphorylation, ATP demand, and reactive oxygen species generation.Biophysical journal,110(4), 962-971. Capaldi, R. A., Aggeler, R. (2002). Mechanism of the F1F0-type ATP synthase, a biological rotary motor.Trends in biochemical sciences,27(3), 154-160. Hahn, A., Parey, K., Bublitz, M., Mills, D. J., Zickermann, V., Vonck, J., ... Meier, T. (2016). Structure of a complete ATP synthase dimer reveals the molecular basis of inner mitochondrial membrane morphology.Molecular cell,63(3), 445-456. Jonckheere, A. I., Smeitink, J. A., Rodenburg, R. J. (2012). Mitochondrial ATP synthase: architecture, function and pathology.Journal of inherited metabolic disease,35(2), 211-225. Junge, W., Nelson, N. (2015). ATP synthase.Annual review of biochemistry,84, 631-657. Martin, J., Hudson, J., Hornung, T., Frasch, W. D. (2015). Fo-driven Rotation in the ATP Synthase Direction against the Force of F1 ATPase in the FoF1 ATP Synthase.Journal of Biological Chemistry,290(17), 10717-10728. Nath, S., Villadsen, J. (2015). Oxidative phosphorylation revisited.Biotechnology and bioengineering,112(3), 429-437. Nelson, D., Cox, M., Lehninger, A. (2012).Lehninger Principles of biochemistry(6th ed.). New York: W.H.Freeman and Co. Senior, A. E., Nadanaciva, S., Weber, J. (2002). The molecular mechanism of ATP synthesis by F1F0-ATP synthase.Biochimica et Biophysica Acta (BBA)-Bioenergetics,1553(3), 188-211. Toei, M., Noji, H. (2013). Single-molecule analysis of F0F1-ATP synthase inhibited by N, N-dicyclohexylcarbodiimide.Journal of Biological Chemistry,288(36), 25717-25726.